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Phenotype: abnormal pro-B cell morphology

Definition
any structural anomaly of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs
Synonyms
abnormal progenitor B cell,  pro-B cell abnormalities,  abnormal B cell progenitor
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal pro-B cell morphology

Total number of significant genotype-phenotype associations: 2

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased pre-pro B cell number Pre-pro B cells (Hardy fraction A) - % of CD45+
Bone marrow immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult increased pro-B cell number Pro-B cells (Hardy fraction B) - % of B220+
Bone marrow immunophenotyping		 WTSI
3i		 0.00

Download data as:   TSV   XLS

 The way we measure

Procedure
Bone marrow immunophenotyping

 Phenotype associations stats

0.47% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal pro-B cell morphology (2/424)

0.00% females (0/2) 0.00% males (0/2)

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